DskA is required for the regulation of rrn  transcription by these two small molecules. Indeed, rrn  transcription is insensitive to iNTP and ppGpp in mutants lacking DskA.

TLS Online TPP Program

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#Unit 4. Cell Communication and Cell Signaling

TLS Online TPP Program

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#Unit 4. Cell Communication and Cell Signaling

TLS Online TPP Program

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#Unit 4. Cell Communication and Cell Signaling

NGF, PDGF, FGF, EGF, insulin are RTK ligands, which trigger proliferation of cells.

TLS Online TPP Program

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#Unit 4. Cell Communication and Cell Signaling

The cytosolic domain of RTKs contains an intrinsic protein tyrosine kinase domain.

TLS Online TPP Program

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#Unit 4. Cell Communication and Cell Signaling

Cytosolic kinase domain of an RTK contains a flexible domain termed activation loop. 

TLS Online TPP Program

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#Unit 4. Cell Communication and Cell Signaling

In resting state,  the activation loop is not phosphorylated and assumes a conformation that blocks kinase activity.

In insulin receptor, it prevents binding of ATP. 

In FGF receptor, it prevents binding of substrate.