XMAP215 binds free tubulin subunits and delivers them to the plus end of a microtubule, dramatically accelerating polymerization.

TLS Online TPP Program

#Id: 8915

#Unit 2. Cellular Organization

Mitotic exit network plays an important role in shutting off mitotic cyclins by controlling the activation of the Cdc14 phosphatase through a GTPase pathway.

TLS Online TPP Program

#Id: 8916

#Unit 2. Cellular Organization

Cytokinesis

With the exception of higher plants, the division of the cell is brought about by a contractile ring made of actin and myosin

TLS Online TPP Program

#Id: 8917

#Unit 2. Cellular Organization

TLS Online TPP Program

#Id: 8918

#Unit 2. Cellular Organization

Centralspindlin is a heterotetramer composed of two copies of the kinesin-6 motor protein MKLP1 and a dimer of a Rho GAP

TLS Online TPP Program

#Id: 8919

#Unit 2. Cellular Organization

MKLP1 is inhibited by 14-3-3 to ensures that the spindle midzone microtubules do not compact until the end of anaphase

TLS Online TPP Program

#Id: 8920

#Unit 2. Cellular Organization

During anaphase, when cyclin B-CDK1 activity is extinguished but Aurora and Polo kinases are still active, Aurora B phosphorylates MKLP1 and displaces the 14-3-3, allowing compact the spindle midzone.