TF11S displays little similarity in sequence or structure to the Gre factors, but it binds to the same part of the enzyme, the RNA polymerase secondary channel (pore). 

TLS Online TPP Program

#Id: 6401

#Unit 2. Cellular Organization

Attenuator riboswitch (Leader sequence) is made up of almost 140 nt which further can be divided into four Intra -complementary regions 

TLS Online TPP Program

#Id: 6402

#Unit 2. Cellular Organization

Attenuator riboswitch (Leader sequence) contains two major check-points in region 1

UGG codons on position 10, 11

A stop codon UGA between Region 1 and 2

TLS Online TPP Program

#Id: 6403

#Unit 2. Cellular Organization

Attenuator riboswitch (Leader sequence) region 1 is translated atleast till codon 10 and 11 in case of Low trp concentration

TLS Online TPP Program

#Id: 6404

#Unit 2. Cellular Organization

Region 1 Leader peptide is of 14 Amino acids Met------Ser 

TLS Online TPP Program

#Id: 6405

#Unit 2. Cellular Organization

At high or low trp concentration, RNA Polymerase synthesizes full mRNA till region 4

TLS Online TPP Program

#Id: 6406

#Unit 2. Cellular Organization

Attenuator riboswitch (Leader sequence) region 1 is translated  till UGA (R1-2) at high trp concentration due to two conditions

 Ribosome quickly crosses codon 10, 11

After crossing codon 10, 11 ribosome prematurely terminated at UGA at the end of Region 1