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#Unit 3. Fundamental Processes
The use of a single type of catalytic subunit, however, may be atypical. In the bacterium Bacillus subtilis, there are two different catalytic subunits.
PolC is the homolog to E. coli's DnaE, and is responsible for synthesizing the leading strand.
A related protein, DnaE8 s. is the catalytic subunit that synthesizes the lagging strand.