Readthrough transcripts refer to the fraction of transcripts that are not stopped by the terminator. (Readthrough is the same term used in translation to describe a ribosome’s suppression of termination codons.) 

TLS Online TPP Program

#Id: 3271

#Unit 3. Fundamental Processes

Chemicals that are found to be mutagenic in the Ames test can then be tested for their potential carcinogenic effects in animals.

TLS Online TPP Program

#Id: 3272

#Unit 3. Fundamental Processes

Mismatch Repair Correction of the rare mismatches left after replication in E. coli improves the overall fidelity of replication by an additional factor of 10^2 to 10^3.

TLS Online TPP Program

#Id: 3273

#Unit 3. Fundamental Processes

The mismatch repair system of E. coli includes at least 12 protein components (Table) that function either in strand discrimination or in the repair process itself.

TLS Online TPP Program

#Id: 3277

#Unit 3. Fundamental Processes

Methylation of DNA strands can serve to distinguish parent (template) strands from newly synthesized strands in E. coli DNA

TLS Online TPP Program

#Id: 3279

#Unit 3. Fundamental Processes

 In Escherichia coli, mismatches are detected by a dimer of the mismatch repair protein MutS.

TLS Online TPP Program

#Id: 3280

#Unit 3. Fundamental Processes

MutS embraces the mismatch-containing DNA, inducing a pronounced kink in the DNA and a conformational change in MutS itself.