The greater the effective nuclear charge the more tightly an electron is held in by the nucleus because there is less electron shield between the valence electrons and the nucleus, and so, the smaller the radius.

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The Mammalian genome could be replicated in -1 hour if all replicons functioned simultaneously.

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#Unit 3. Fundamental Processes

Most chromosomal replicons do not have a termination region like that of bacteria at which the replication forks cease movement and (presumably) dissociate from the DNA. 

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#Unit 3. Fundamental Processes

individual replicons in eukaryotic genomes are relatively small, typically -40 kb in yeast or flies and -100 kb in animal cells.

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Origins in S. cerevisiae are short A-T sequences that have an essential 11-bp sequence.

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#Unit 3. Fundamental Processes

The ORC is a complex of six proteins that binds to an ARS.

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Related ORC complexes are found in multicellular eukaryotes.