Slab gels can develop a “Smiling Effect” When in a gel more Joule heat is produced than can be dissipated, leads to the higher mobility of the ions in the center, resulting in an uneven distribution of the zones, These zones bend up at the two lateral sides, causing “smiling.” 

TLS Online TPP Program

#Id: 8590

#Unit 2. Cellular Organization

Mitotic CDKs drive phosphorylation of lamins A, B, and C results in disassembly of the intermediate filament lattice into lamin dimers.

TLS Online TPP Program

#Id: 8591

#Unit 2. Cellular Organization

Due to C-terminal prenylation of lamin B, 

lamin B dimers remain associated with the nuclear

membrane

TLS Online TPP Program

#Id: 8592

#Unit 2. Cellular Organization

During telophase, de-phosphorylation by specific phosphatases promotes lamin reassembly, which is critical to re-formation of a nuclear envelope around the daughter chromosomes.

TLS Online TPP Program

#Id: 8593

#Unit 2. Cellular Organization

Laminopathies 

Mutation in lamin A

TLS Online TPP Program

#Id: 8594

#Unit 2. Cellular Organization

Emery-Dreifuss muscular dystrophy (EDMD)

mutations in emerin, a nesprin and a SUN protein

TLS Online TPP Program

#Id: 8595

#Unit 2. Cellular Organization

Mutations in lamin A 

cause progeria accelerated aging, such as Hutchison-Gilford progeria (“prematurely old”)