Slab gels can develop a “Smiling Effect” When in a gel more Joule heat is produced than can be dissipated, leads to the higher mobility of the ions in the center, resulting in an uneven distribution of the zones, These zones bend up at the two lateral sides, causing “smiling.” 

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#Unit 5. Developmental Biology

B cell is type of lymphocyte. B cell synthesized and maturation in Bone marrow.

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#Id: 7238

#Unit 5. Developmental Biology

Stages in hematopoiesis

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#Unit 5. Developmental Biology

B cell properties 

They are APCs

They can express MHC2

Have surface marker  CD19

Antibodies at surface of b cell – IgM, IgD

Part of Adaptive immunity 

B cell convert into plasma cell

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#Id: 7240

#Unit 5. Developmental Biology

Surface protein on B cell

CR2(CR21)

CD19

TAPA-1(CD81)

mIg 

Igα/ Igβ

(CD79a and CD79B)

TLR

CD40

B7 (CD80/86)

ICAM-1

MHC-1 and 2

CD 22

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#Unit 5. Developmental Biology

Formation of mature B-cell

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#Unit 5. Developmental Biology

Progress through their developmental program