Surface protein on B cell

CR2(CR21)

CD19

TAPA-1(CD81)

mIg 

Igα/ Igβ

(CD79a and CD79B)

TLR

CD40

B7 (CD80/86)

ICAM-1

MHC-1 and 2

CD 22

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Classes of Antibody Heavy Chains

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Antibody Light Chains

Light chain was extremely variable, whereas the sequence of the carboxyl-terminal half could be classified into one of two major sequence types.

κ (kappa) 

λ (lambda) 

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Chromosomal locations of immunoglobulin genes

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IgM antibodies are produced first in a humoral immune response and tend to be of low affinity.

IgM molecules form pentamers that are stabilized by a single J-chain molecule.

This higher avidity of the pentamer compensates for the low affinity

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IgG efficiently opsonizes pathogens for engulfment by phagocytes and activates the complement system. The affinity of the individual antigen binding sites for their antigen is therefore critical for the effectiveness of these antibodies, and most of the B cells expressing these classes have been selected in the germinal centers for their increased affinity for antigen after somatic hyper mutation.