Lys & Arg have four ionisations zones

1. 1--------pK1 – charge +2

2. pK1---------pK2 charge +1

3. pK2---------pKr charge 0

4. pKr---------14 charge -1

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#Unit 7. System Physiology – Animal

Conn syndrome (primary hyperaldosteronism) caused by an aldosterone-secreting tumor.

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#Unit 7. System Physiology – Animal

Principal catecholamines synthesized by the adrenal medulla:

Norepinephrine

Epinephrine

Dopamine

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#Unit 7. System Physiology – Animal

Norepinephrine is formed by hydroxylation and decarboxylation of tyrosine

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#Unit 7. System Physiology – Animal

Some of the tyrosine is formed from phenylalanine, by Phenylalanine hydroxylase

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#Unit 7. System Physiology – Animal

Tetrahydrobiopterin (BH4) is a cofactor for tyrosine hydroxylase and phenylalanine hydroxylase

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#Unit 7. System Physiology – Animal

Phenylketonuria (PKU) 

Mutation of the gene for phenylalanine hydroxylase

Caused by tetrahydrobiopterin (BH4) deficiency