Transcellular Pathway

Water and solutes can be transported through the cell membranes by passive diffusion or active transport.

Water and solutes can be transported through the cell membranes by passive diffusion or active transport.

TLS Online TPP Program

#Id: 1103

#Unit 2. Cellular Organization

Na+–K+ ATPase, consists of two types of subunits: 

α2 subunit

β2 subunit

TLS Online TPP Program

#Id: 1104

#Unit 2. Cellular Organization

Transmembrane domain with the binding sites for transported ligand.

TLS Online TPP Program

#Id: 1105

#Unit 2. Cellular Organization

Phosphorylation domain contains the canonical Asp351 phosphorylated.

TLS Online TPP Program

#Id: 1106

#Unit 2. Cellular Organization

Nucleotide binding domain serves as a built-in protein kinase that functions to phosphorylate the P domain.

TLS Online TPP Program

#Id: 1107

#Unit 2. Cellular Organization

Actuator domain has protein phosphatase activity and removes the phosphoryl group from the Asp residue

TLS Online TPP Program

#Id: 1108

#Unit 2. Cellular Organization

E1’s ion-binding sites are exposed to the cytoplasm, and it has high affinity for Na+ but low affinity for K+