End-labelling of a gene probe at the 3′ end using terminal transferase. Note that the addition of a labeled dNTP at the 3′ end alters the sequence of the gene probe.

TLS Online TPP Program

#Id: 8345

#Unit 2. Cellular Organization

TLS Online TPP Program

#Id: 8346

#Unit 2. Cellular Organization

Formins are activated by membrane-bound Rho-GTP, a Ras-related small GTPase

TLS Online TPP Program

#Id: 8347

#Unit 2. Cellular Organization

To nucleate the assembly of branched actin filaments, Arp2/3 needs to be activated by a nucleation promoting factor (NPF)

TLS Online TPP Program

#Id: 8348

#Unit 2. Cellular Organization

The major NPF family is characterized by the presence of a region called WCA (WH2, connector, acidic)

TLS Online TPP Program

#Id: 8349

#Unit 2. Cellular Organization

TLS Online TPP Program

#Id: 8350

#Unit 2. Cellular Organization

One NPF is called WASp, as it is defective in patients with Wiskott-Aldrich syndrome.