Footprinting is a means of finding the target DNA sequence, or binding site, of a DNA-binding protein.

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#Id: 5782

#Unit 7. System Physiology – Animal

Colloid consists predominantly of the glycoprotein, thyroglobulin

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#Id: 5783

#Unit 7. System Physiology – Animal

The primary hormone secreted by the thyroid is thyroxine (T4) along with much lesser amounts of triiodothyronine (T3)

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#Id: 5784

#Unit 7. System Physiology – Animal

Basolateral membranes of thyrocytes contain a symporter Na+/I –symporter (NIS) 

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#Id: 5785

#Unit 7. System Physiology – Animal

Process of concentrating the iodide in the cell is called iodide trapping

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#Id: 5786

#Unit 7. System Physiology – Animal

Na+/I – symporter (NIS) is capable of producing intracellular I – concentrations that are 20– 40 times as great as the concentration in plasma

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#Id: 5787

#Unit 7. System Physiology – Animal

Wolff –Chaikoff effect large doses of iodide act directly on the thyroid to produce a mild and transient inhibition of organic binding of iodide and hence of hormone synthesis.