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DNase and DMS, other reagents are commonly used to footprint protein–DNA complexes by breaking DNA except where it is protected by bound proteins. For example, organometallic complexes containing copper or iron act by generating hydroxyl radicals that attack and break DNA strands.




#Unit 13. Methods in Biology #DNA sequencing methods- Footprinting Assays #Part B Pointers
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#Unit 11. Evolution and Behavior

A recessive allele (a) that causes a genetic disease has a frequency (q) of 0.01. If the population mates randomly (F = 0), the frequency of individuals affected by the disease (aa) will be q = 0.01 = 0.0001.
However, if F = 0.25 expected frequency of the aa is .0026.

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#Unit 11. Evolution and Behavior

Effects of inbreeding on Japanese children

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#Unit 11. Evolution and Behavior

Negative assortative mating refers to a tendency for unlike individuals to mate. people engaged in negative assortative mating for height.
Increases the frequency of heterozygous genotypes (Aa).

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#Unit 11. Evolution and Behavior

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#Unit 11. Evolution and Behavior

Mutation
Mutation has changed the allelic frequency.
it increases genetic variation within populations and between population.

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#Unit 11. Evolution and Behavior

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