t’R is characteristic of the analyte and is the difference between the observed retention time and the dead time:

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#Id: 6917

#Unit 8. Inheritance Biology

Unbalanced gene dosage leads to developmental abnormalities.

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#Id: 6918

#Unit 8. Inheritance Biology

Chromosome deletion 

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#Id: 6919

#Unit 8. Inheritance Biology

Chromosome deletion - Loss of a chromosome segment.

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#Id: 6920

#Unit 8. Inheritance Biology

Deletion include,
Terminal deletion

ntercalary/interstitial deletion 

Microdeletion

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#Id: 6921

#Unit 8. Inheritance Biology

Cri-du- chat syndrome- Deletion on 5, short arm

Wolf– Hirschhorn syndrome- Deletion on 4, short arm

Williams– Beuren syndrome - Deletion on 7, long arm

Prader– Willi syndrome- Deletion on 15 long arm 

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#Id: 6922

#Unit 8. Inheritance Biology

Deletion of a number of pairs that is not evenly divisible by three will lead to a frameshift mutation.