The key event in controlling replication is the behavior of the ORC complex at the origin.

Cdc6 protein is an unstable protein that is synthesized only in G1.

Cdc6 binds to ORC and allows MCM proteins.

Cdc6 binds to ORC and allows MCM proteins to bind.

Cdt1 facilitates MCM loading on origins

TLS Online TPP Program

#Id: 9473

#Unit 4. Cell Communication and Cell Signaling

SHP1 a phosphotyrosine phosphatase, contains:

SH2 domain  & Phosphatase domain

TLS Online TPP Program

#Id: 9474

#Unit 4. Cell Communication and Cell Signaling

SHP1 

Binding of an SH2 domain to a phosphotyrosine in the activated receptor unmasks its phosphatase catalytic site

TLS Online TPP Program

#Id: 9475

#Unit 4. Cell Communication and Cell Signaling

SHP1 causes removal of the phosphate from tyrosine in the activation loop of JAK2 & inactivates the JAK kinase.

TLS Online TPP Program

#Id: 9476

#Unit 4. Cell Communication and Cell Signaling

SOCS proteins 

expression is induced by the STAT5 in erythroid progenitor cells, inhibit or permanently terminate signaling over longer periods

TLS Online TPP Program

#Id: 9477

#Unit 4. Cell Communication and Cell Signaling

All SOCS proteins contains:

SH2 domain

SOCS box

TLS Online TPP Program

#Id: 9478

#Unit 4. Cell Communication and Cell Signaling

SOCS box, 

Recruits E3 ubiquitin ligases that polyubiquitinylate the receptor and the JAK kinase & marks the proteins for destruction by a proteasome