That not all of the fragment population represents bona fide Okazaki fragments; some are pseudo fragments that have been generated by breakage in a DNA strand that actually was synthesized as a continuous chain. The source of this breakage is the incorporation of some uracil into DNA in place of thymine. When the uracil is removed by a repair system, the leading strand has breaks until a thymine is inserted.
#Unit 3. Fundamental Processes#Fidelity of replication#Part B Pointers