The richness of some areas is increased by the presence of corridors

TLS Online TPP Program

#Id: 10489

#Unit 4. Cell Communication and Cell Signaling

Cytotoxic T cells release granules containing the proteins perforin and granzyme-B

TLS Online TPP Program

#Id: 10490

#Unit 4. Cell Communication and Cell Signaling

perforins punch holes in the endocytic vesicle membrane, allowing granzymes to enter the cytoplasm

TLS Online TPP Program

#Id: 10491

#Unit 4. Cell Communication and Cell Signaling

TLS Online TPP Program

#Id: 10492

#Unit 4. Cell Communication and Cell Signaling

Granzymes are serine proteases and cleave and activate

apoptotic molecules within the target cells, causing programmed cell death.

TLS Online TPP Program

#Id: 10493

#Unit 4. Cell Communication and Cell Signaling

Some Cytotoxic T cells express on their surface FasL, a natural ligand molecule related to TNF

TLS Online TPP Program

#Id: 10494

#Unit 4. Cell Communication and Cell Signaling

FasL on the cytotoxic T cell binds to its receptor, the Fas protein on the tumor cells, an apoptotic signaling pathway in the tumor cells becomes activated, which leads to tumor cell death.