The GATC sites at the origin remain hemimethylated for -13 minutes after replication.

TLS Online TPP Program

#Id: 6136

#Unit 3. Fundamental Processes

XPC detect distortions = UvrA in E. coli

Formation of the bubble involves the helicase activities of the proteins XPA and XPD (the equivalent to UvrB in E. coli) and the single-strand-binding protein RPA. The bubble creates cleavage sites 5’ to the lesion for a nuclease known as ERCC1-XPF and 3’ to the lesion for nuclease XPG (representing the function of UvrC). In higher cells, the resulting DNA strand is 24–32 nucleotides long. As in bacteria, the DNA strand is released to create a gap that is filled in by the action of DNA polymerase and ligase.

XPB and XPD are both helicases; the XPB helicase is required for promoter melting during transcription, while the XPD helicase performs the unwinding function in NER

TLS Online TPP Program

#Id: 4547

#Unit 12. Applied Biology

TLS Online TPP Program

#Id: 1490

#Unit 4. Cell Communication and Cell Signaling

p53 transcription is upregulated by growth factor stimulation, as the cell begins preparation for its trip through GI and the important GI to S transition.

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#Id: 5672

#Unit 7. System Physiology – Animal

Hair processes provide a mechanism for generating changes in membrane potential proportional to the

direction and distance the hair moves

TLS Online TPP Program

#Id: 6006

#Unit 3. Fundamental Processes

ATP is required for the binding, but is not hydrolyzed until a later stage. The transcription factor ABF1 binds to the B3 element; this assists initiation by affecting chromatin structure, but it is the events that occur at the A and B1 elements that actually cause initiation