Each set of ter sites allows a replication fork into the termination region, but does not allow it out the other side.For example, replication fork 1 can pass through terC and terB into the region, but it cannot continue past terE, -D, and -A. This arrangement creates a "replication fork trap."

TLS Online TPP Program

#Id: 881

#Unit 13. Methods in Biology

Most STRs are found in the noncoding regions, while only about 8% locate in the coding regions.

TLS Online TPP Program

#Id: 882

#Unit 13. Methods in Biology

The genetic diseases caused by trinucleotide repeat SSRs within genes. Huntington disease (HD) is one of the approximately 20 such trinucleotide repeat diseases in humans. HD is transmitted as an autosomal dominant mutation.

TLS Online TPP Program

#Id: 883

#Unit 13. Methods in Biology

In humans, chromosome 19 has the highest density of STRs. Disease associated with SSR are called as Repeat expansion diseases.

TLS Online TPP Program

#Id: 884

#Unit 13. Methods in Biology

Most common cause of Repeat expansion is SLIPPAGE during replications.

TLS Online TPP Program

#Id: 885

#Unit 13. Methods in Biology

On average, one STR occurs per 2,000 bp in the human genome.

TLS Online TPP Program

#Id: 886

#Unit 13. Methods in Biology

The most common STRs in humans are A-rich units: A, AC, AAAN, AAN, and AG. The STR locus is named as, for example, D3S1266, where D represents DNA, 3 means chromosome 3 on which the STR locus locates, S stands for STR, and 1266 is the unique identifier.