Mitochondria use different origin sequences to initiate replication of each DNA strand

Replication of the H strand is initiated in a D loop.

Replication of the L strand is initiated when its origin is exposed by the movement of the first replication fork.

TLS Online TPP Program

#Id: 8624

#Unit 2. Cellular Organization

TLS Online TPP Program

#Id: 8625

#Unit 2. Cellular Organization

Human SCF complexes contain: 

Three core components - Cul1 subunit, RBX1, Skp1 

and a substrate-targeting F-box protein

TLS Online TPP Program

#Id: 8626

#Unit 2. Cellular Organization

RBX1 is a RING finger–containing protein that binds the E2 ubiquitin-conjugating enzyme.

TLS Online TPP Program

#Id: 8627

#Unit 2. Cellular Organization

phosphoserine/threonine-binding F-box protein is Skp2, which uses a series of leucine-rich repeats to bind to target proteins only when they are phosphorylated.

TLS Online TPP Program

#Id: 8628

#Unit 2. Cellular Organization

APC/C consists of 14 core subunits in metazoans and 13 core subunits in yeast.

TLS Online TPP Program

#Id: 8629

#Unit 2. Cellular Organization

APC/C works with substrate-targeting factors called Cdc20 and Cdh1