Mitochondria use different origin sequences to initiate replication of each DNA strand

Replication of the H strand is initiated in a D loop.

Replication of the L strand is initiated when its origin is exposed by the movement of the first replication fork.

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Tissue thromboplastin and factor VII activate factors IX and X.

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#Unit 7. System Physiology – Animal

In the presence of PL, Ca2+ , & factor V, activated factor X catalyzes the conversion of prothrombin to thrombin.

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#Unit 7. System Physiology – Animal

Thrombin is a serine protease that is formed from its circulating precursor, prothrombin, by the action of activated factor X.

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#Unit 7. System Physiology – Animal

The conversion of fibrinogen to fibrin is catalyzed by thrombin.

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Stabilization of fibrin is catalyzed by activated factor XIII and Ca2

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#Unit 7. System Physiology – Animal

The extrinsic pathway is inhibited by a tissue factor pathway inhibitor that forms a quaternary structure with tissue thromboplastin (TPL), factor VIIa, and factor Xa.