Mitochondria use different origin sequences to initiate replication of each DNA strand

Replication of the H strand is initiated in a D loop.

Replication of the L strand is initiated when its origin is exposed by the movement of the first replication fork.

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#Unit 3. Fundamental Processes

Activity of the replication origin is controlled is DNA methylation

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#Unit 3. Fundamental Processes

The E. coli oriC contains 11 copies of the GATC sequence

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#Unit 3. Fundamental Processes

GATC is a target for methylation at the N6 position of A by Dam Methylase enzyme which uses SAM as methyl group donor

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#Unit 3. Fundamental Processes

Several of methylation sites overlap dnaA boxes

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#Unit 3. Fundamental Processes

DnaA is an ATP-binding protein and its binding to DNA is affected depending on whether ATP

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#Unit 3. Fundamental Processes

DnaA is the E. coli licensing factor that must be made anew for each round of replication.