7,8-diol-9,10-epoxide is responsible for cancer development forms an adduct with guanine:

(+)-trans-anti-B-(a)-P-N superscript 2-d G adduct

TLS Online TPP Program

#Id: 5826

#Unit 7. System Physiology – Animal

Addison disease (primary adrenocortical insufficiency) caused by autoimmune destruction of all zones of the adrenal cortex.

TLS Online TPP Program

#Id: 5827

#Unit 7. System Physiology – Animal

Cushing syndrome Chronic excess of glucocorticoids (hypersecretion of ACTH from a pituitary adenoma)

TLS Online TPP Program

#Id: 5828

#Unit 7. System Physiology – Animal

Conn syndrome (primary hyperaldosteronism) caused by an aldosterone-secreting tumor.

TLS Online TPP Program

#Id: 6505

#Unit 7. System Physiology – Animal

Principal catecholamines synthesized by the adrenal medulla:

Norepinephrine

Epinephrine

Dopamine

TLS Online TPP Program

#Id: 6506

#Unit 7. System Physiology – Animal

Norepinephrine is formed by hydroxylation and decarboxylation of tyrosine

TLS Online TPP Program

#Id: 6507

#Unit 7. System Physiology – Animal

Some of the tyrosine is formed from phenylalanine, by Phenylalanine hydroxylase