oxoG:A repair, Oxidation of guanine produces oxoG. 

The modified base can be repaired before replication by DNA glycosylase via the base excision pathway. 

If replication occurs before the oxoG is removed, resulting in the misincorporation of an A, then a fail-safe glycosylase can remove the A, allowing it to be replaced by a C. 

This provides a second opportunity for the DNA glycosylase to remove the modified base.

TLS Online TPP Program

#Id: 2379

#Unit 3. Fundamental Processes

Prp8, a large scaffold protein that directly contacts both the 5’ and 3’ splice sites within the spliceosome.

TLS Online TPP Program

#Id: 2380

#Unit 3. Fundamental Processes

Prp5 is critical for U2 binding

TLS Online TPP Program

#Id: 2381

#Unit 3. Fundamental Processes

Brr2 facilitates U1 and U4 release

TLS Online TPP Program

#Id: 2382

#Unit 3. Fundamental Processes

Prp2 is responsible for the activation of the spliceosome Prp22 helps the release of the mature mRNA from the spliceosome

TLS Online TPP Program

#Id: 2383

#Unit 3. Fundamental Processes

Prp22 helps the release of the mature mRNA from the spliceosome, makes splicing irreversible.

TLS Online TPP Program

#Id: 2384

#Unit 3. Fundamental Processes

More than 90% of the genes expressed in mammals are alternatively spliced