Not only is nucleotide excision repair capable of mending damage throughout the genome, but it is also capable of rescuing RNA polymerase, the progression of which has been arrested by the presence of a lesion in the transcribed (template) strand of a gene, this phenomenon, known as transcription-coupled repair.

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#Unit 3. Fundamental Processes

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#Unit 3. Fundamental Processes

How tightly does core enzyme v. holoenzyme bind DNA?

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#Unit 3. Fundamental Processes

The effect of temperature on the dissociation of the polymerase–T7 DNA complex. 

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#Unit 3. Fundamental Processes

higher temperature favors tighter binding between RNA polymerase holoenzyme and T7 DNA

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#Unit 3. Fundamental Processes

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#Unit 3. Fundamental Processes

Isomerization, does not require energy derived from ATP hydrolysis and is instead the result of a spontaneous conformational change in the DNA– enzyme complex to a more energetically favorable form.