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TLS Online TPP Program

#Id: 3374

Translesion synthesis replicates across the DNA lesion, but the lesion remains in the genome until a DNA repair pathway can subsequently correct the damage.

#Unit 3. Fundamental Processes #DNA damage and repair mechanisms #Part B Pointers
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TLS Online TPP Program

#Id: 1678

#Unit 4. Cell Communication and Cell Signaling

Multiple gene segments exist at heavy (V, D, and J) and light-chain (V and J) loci.
TLS Online TPP Program

#Id: 1679

#Unit 4. Cell Communication and Cell Signaling

Junctional diversity- P and N nucleotides  addition
TLS Online TPP Program

#Id: 1680

#Unit 4. Cell Communication and Cell Signaling

P nucleotide addition results when the DNA hairpin at the coding joint is cleaved asymmetrically.
TLS Online TPP Program

#Id: 1681

#Unit 4. Cell Communication and Cell Signaling

Non - templated N nucleotide addition in heavy chains results from TdT activity.
TLS Online TPP Program

#Id: 1682

#Unit 4. Cell Communication and Cell Signaling

Exonuclease trimming sometimes occurs at the VDJ and VJ junctions, causing loss of nucleotides.
TLS Online TPP Program

#Id: 1683

#Unit 4. Cell Communication and Cell Signaling

Combinatorial diversity: The same heavy chain can combine with different light chain