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TLS Online TPP Program

#Id: 3393

Because of its high error rate, translesion synthesis (like NHEJ) can be considered a system of last resort. It enables the cell to survive what might otherwise be a catastrophic block to replication, but the price that is paid is a higher level of mut


#Unit 3. Fundamental Processes #DNA damage and repair mechanisms #Part B Pointers
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TLS Online TPP Program

#Id: 7965

#Unit 2. Cellular Organization

Unassembled or misfolded proteins in the ER are often transported back to the cytosol, where they are degraded in the ubiquitin-proteasome pathway
TLS Online TPP Program

#Id: 7966

#Unit 2. Cellular Organization

Binding of BiP to the luminal domain of monomeric Ire1 prevents formation of the Ire1 dimer.
TLS Online TPP Program

#Id: 7967

#Unit 2. Cellular Organization

Hydrolysis of the bound GTP accompanies disassembly of the SRP and SRP receptor and initiates transfer of the nascent chain and ribosome to a site on the ER membrane, where translocation can take place.
TLS Online TPP Program

#Id: 8135

#Unit 2. Cellular Organization

The Golgi consists of four functionally distinct regions:

a. Cis compartments

b. Medial compartments

c. Trans compartments

d. Trans-Golgi network
TLS Online TPP Program

#Id: 8136

#Unit 2. Cellular Organization

Golgi apparatus is a major site of carbohydrate synthesis, as well as a sorting and dispatching station for proteins products.
TLS Online TPP Program

#Id: 8137

#Unit 2. Cellular Organization

In animal cells,
Most of the glycosaminoglycans of the extracellular matrix are synthesized in golgi apparatus.