The holoenzyme is a complex of 900 kD that contains 10 different proteins organized into four types of subcomplex
1. Atleast two copies of the catalytic core.
2. two copies of the dimerizing subunit, t, which link the two catalytic cores together.
3. There are two copies of the clamp
4. The g complex is a group of seven proteins, encoded by five genes, that comprise the clamp loader
