Nuclear lamina

Fibrous network on the inner surface of the nuclear envelope composed of lamin intermediate filaments that provides structural support for the nuclear envelope and also acts as an anchoring site for chromosomes.

TLS Online TPP Program

#Id: 445

#Unit 2. Cellular Organization

Core DNA has an invariant length of 146 bp, the minimum length of DNA needed to form a stable monomeric nucleosome, and is relatively resistant to digestion by nucleases- DNA FINGER PRINTING

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#Id: 446

#Unit 2. Cellular Organization

Linker DNA comprises the rest of the repeating unit. Its length varies from as little as 8 bp to as many as 114 bp per nucleosome.

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#Id: 447

#Unit 2. Cellular Organization

The predicted mass of the nucleosome is 262 kD.

TLS Online TPP Program

#Id: 448

#Unit 2. Cellular Organization

The nucleosome consists of approximately equal masses of DNA and histones (including H1).

TLS Online TPP Program

#Id: 449

#Unit 2. Cellular Organization

H32-H42 tetramer accounts for the diameter of the octamer. It forms the shape of a horseshoe.

TLS Online TPP Program

#Id: 450

#Unit 2. Cellular Organization

All four core histones show a similar type of structure in which three a-helices are connected by two loops. This highly conserved structure is called the histone fold.