Mutations that remove the 2'-OH of the A residue at the 3' end of the P-site tRNA result in a 10⁶ -fold reduction in catalysis rates.

TLS Online TPP Program

#Id: 10454

#Unit 4. Cell Communication and Cell Signaling

BCR-ABL fusion protein is a constitutively active

kinase that phosphorylates multiple signal-transducing proteins. 

TLS Online TPP Program

#Id: 10455

#Unit 4. Cell Communication and Cell Signaling

Chronic myelogenous leukemia, 

a common leukemia in humans, associated with the Philadelphia chromosome

TLS Online TPP Program

#Id: 10456

#Unit 4. Cell Communication and Cell Signaling

A highly specific inhibitor imatinib (Gleevec), which

binds directly to the active site of the ABL kinase and holds it in an inactive conformation to inhibit its kinase activity, is lethal to CML cells

TLS Online TPP Program

#Id: 10458

#Unit 4. Cell Communication and Cell Signaling

TLS Online TPP Program

#Id: 10459

#Unit 4. Cell Communication and Cell Signaling

Inappropriate production of nuclear transcription factors such as FOS, JUN, and MYC can induce transformation.

TLS Online TPP Program

#Id: 10460

#Unit 4. Cell Communication and Cell Signaling

Burkitt’s lymphoma

translocation between chromosomes 8 and 14