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TLS Online TPP Program

#Id: 3666

Aminoacyl-tRNA Formation Is Very Accurate, the frequency of mischarging is very low; typically, less than 1 in 1000 tRNAs is charged with the incorrect amino acid.

#Unit 3. Fundamental Processes #Translation initiation factors and their regulation #Part B Pointers
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TLS Online TPP Program

#Id: 9067

#Unit 4. Cell Communication and Cell Signaling

Phosphorylated CREB binds to CRE-containing target genes and also binds to the co-activator termed CBP/P300, thereby stimulating gene transcription
TLS Online TPP Program

#Id: 9068

#Unit 4. Cell Communication and Cell Signaling
TLS Online TPP Program

#Id: 9069

#Unit 4. Cell Communication and Cell Signaling

Inactive PKA is a tetramer consisting of- 
two regulatory (R) subunits
two catalytic (C) subunits
TLS Online TPP Program

#Id: 9070

#Unit 4. Cell Communication and Cell Signaling

Two large classes of GTPase switch proteins are used in signal transduction pathways:

1. Heterotrimeric G proteins

2. Monomeric G proteins
TLS Online TPP Program

#Id: 9071

#Unit 4. Cell Communication and Cell Signaling

Feedback mechanisms suppress signaling by the PKA pathway:
1. Intrinsic GTPase activity of Gαs
2. PDE acts to hydrolyze cAMP to 5′-AMP
3. By BARK
TLS Online TPP Program

#Id: 9072

#Unit 4. Cell Communication and Cell Signaling

In resting state 
basal level of PDE activity keeps cAMP levels below those necessary for PKA activation.