Different thalassemias are caused by various deletions that eliminate a- or b-globin genes. The severity of the disease depends on the individual deletion.

TLS Online TPP Program

#Id: 8143

#Unit 2. Cellular Organization

Vesicle Type- COPII

Transport - ER to cis-Golgi 

Coat Proteins - Sec23/Sec24 and Sec13/Sec31, Sec16

Associated GTPase- Sar1

TLS Online TPP Program

#Id: 8144

#Unit 2. Cellular Organization

Vesicle Type- COPI

Transport - cis-Golgi to ER

Coat Proteins – Coatomers

Associated GTPase- ARF

TLS Online TPP Program

#Id: 8145

#Unit 2. Cellular Organization

Vesicle Type- Clathrin

Transport - trans-Golgi to endosome

Coat Proteins – Clathrin + AP1 complexes

                            Clathrin + GGA

Associated GTPase- ARF

TLS Online TPP Program

#Id: 8146

#Unit 2. Cellular Organization

TLS Online TPP Program

#Id: 8147

#Unit 2. Cellular Organization

A clathrin molecule,

called a triskelion, is composed of : 

Three heavy chains

Three light chains

TLS Online TPP Program

#Id: 8148

#Unit 2. Cellular Organization

Depolymerization of the clathrin coat into triskelions  by Cytosolic Hsp70