Using the clock analogy again, the DNA associated with H2A.H2B is located from 5 o’clock to 9 o’clock on either face of the nucleosome disc.

TLS Online TPP Program

#Id: 8342

#Unit 2. Cellular Organization

TLS Online TPP Program

#Id: 8343

#Unit 2. Cellular Organization

formin family members have two adjacent domains:

FH1- rich in proline, landing site for profilin–ATP–G-actin

FH2 - form a dimer and nucleate filament assembly

TLS Online TPP Program

#Id: 8345

#Unit 2. Cellular Organization

TLS Online TPP Program

#Id: 8346

#Unit 2. Cellular Organization

Formins are activated by membrane-bound Rho-GTP, a Ras-related small GTPase

TLS Online TPP Program

#Id: 8347

#Unit 2. Cellular Organization

To nucleate the assembly of branched actin filaments, Arp2/3 needs to be activated by a nucleation promoting factor (NPF)

TLS Online TPP Program

#Id: 8348

#Unit 2. Cellular Organization

The major NPF family is characterized by the presence of a region called WCA (WH2, connector, acidic)