Addition of a topoisomerase greatly facilitates nucleosome association with cccDNA.

When a topoisomerase is present during nucleosome assembly, it cannot act on the DNA bound to the nucleosome. Instead, the topoisomerase relaxes the DNA not included in nucleosomes, reducing the positive superhelical density in these regions by decreasing the linking number.

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#Id: 9154

#Unit 11. Evolution and Behavior

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#Id: 6294

#Unit 3. Fundamental Processes

In holoenzyme Region 1.1 of s is highly negatively charged hence region 1.1 acts as a molecular mimic of DNA

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#Unit 7. System Physiology – Animal

Colloid consists predominantly of the glycoprotein, thyroglobulin

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#Unit 6. System Physiology – Plant

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#Unit 3. Fundamental Processes

The most well studied type of DE is the AU-rich element (ARE) AUUUA, found in the 3’ UTR of up to 8% of mammalian mRNAs