By maintaining the unbound DNA in a relaxed state, topoisomerases facilitate the binding of histones to the DNA and the formation of additional nucleosomes.

Importantly, the overall effect on the plasmid is that the linking number is decreased as more nucleosomes are assembled

TLS Online TPP Program

#Id: 1338

#Unit 4. Cell Communication and Cell Signaling

The EGFR specifically binds EGF in a lock-and-key type of mechanism.

TLS Online TPP Program

#Id: 1339

#Unit 4. Cell Communication and Cell Signaling

The function of a growth factor-  stabilize receptor dimerization

TLS Online TPP Program

#Id: 1340

#Unit 4. Cell Communication and Cell Signaling

HER1 & HER4, can form stable homodimers after binding a growth factor.

TLS Online TPP Program

#Id: 1341

#Unit 4. Cell Communication and Cell Signaling

HER2 can signal only by forming heterodimers with ligand-bound HER1, HER3, or HER4

TLS Online TPP Program

#Id: 1342

#Unit 4. Cell Communication and Cell Signaling

HER3 lacks a functional kinase domain

TLS Online TPP Program

#Id: 1343

#Unit 4. Cell Communication and Cell Signaling

RAS is a small monomeric G-proteins.