Variants have been identified for all core histones except histone H4.

TLS Online TPP Program

#Id: 9662

#Unit 4. Cell Communication and Cell Signaling

The SH2 domains of PLCγ bind to specific phosphotyrosines on the activated RTKs and cytokine receptors, thus positioning PLCγ close to PIP2.

TLS Online TPP Program

#Id: 9663

#Unit 4. Cell Communication and Cell Signaling

Kinase activity associated with receptor activation phosphorylates tyrosines on the bound PLCγ, enhancing its hydrolase activity. 

TLS Online TPP Program

#Id: 9664

#Unit 4. Cell Communication and Cell Signaling

Activated RTKs and cytokine receptors initiate another phosphoinositide pathway by recruiting PI-3 kinase to the cytosolic surface of the plasma membrane.

TLS Online TPP Program

#Id: 9665

#Unit 4. Cell Communication and Cell Signaling

PI-3 kinase contains SH2 domain which binds to phosphotyrosines on the activated RTKs and cytokine receptors

TLS Online TPP Program

#Id: 9666

#Unit 4. Cell Communication and Cell Signaling

PI-3 kinase adds a phosphate to the 3′ carbon in one of two separate PI substrates, leading to formation of two PI 3-phosphates: PI(3,4)P2 or PI(3,4,5)P3

TLS Online TPP Program

#Id: 9667

#Unit 4. Cell Communication and Cell Signaling

In cells, PI-3 kinase pathway :

Triggers cell division 

Prevents apoptosis

Induces specific changes in cell metabolism