Chromosomes occupy chromosome territories in the nucleus and are not entangled with each other.

Heterochromatic regions, silenced genes, and gene-sparse regions of chromosomes are typically localized to the nuclear periphery.

TLS Online TPP Program

#Id: 1776

#Unit 4. Cell Communication and Cell Signaling

In the presence of antigen and TGF-β, CD8+ regulatory T cells expressing FoxP3 can be induced (iTREG).

TLS Online TPP Program

#Id: 1777

#Unit 4. Cell Communication and Cell Signaling

Three main pathways of CD8+ regulatory T cells:

a. APC lysis

b. Inhibition of APC function

c. Regulation of effector T cells

TLS Online TPP Program

#Id: 1778

#Unit 4. Cell Communication and Cell Signaling

TREG cells were most recently characterized as a unique subset of CD4+ T cells that express high levels of the IL-2R  chain (CD25), the low-affinity receptor for this cytokine.

TLS Online TPP Program

#Id: 1779

#Unit 4. Cell Communication and Cell Signaling

High levels of CD25 was responsible for the suppression of diabetes. 

TLS Online TPP Program

#Id: 1780

#Unit 4. Cell Communication and Cell Signaling

TLS Online TPP Program

#Id: 1781

#Unit 4. Cell Communication and Cell Signaling

Graft Rejection

Autograft is self tissue transferred from one body site to another in the same individual. Isograft is tissue transferred between genetically identical individuals.