Local genome alteration, termed kataegis involves activation-induced deaminase (AID)

Chromothripsis entire chromosomes or large parts thereof are shattered (thripsis in Greek means “shattering”) and stitched together again in what appears to be a random manner, leading to dozens or sometimes even hundreds of rearrangements.

TLS Online TPP Program

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#Unit 3. Fundamental Processes

Replacement of Purine to Purine is called Transition

TLS Online TPP Program

#Id: 630

#Unit 3. Fundamental Processes

Replacement of Pyrimidine to Purine or vice versa is called Transversion.

TLS Online TPP Program

#Id: 631

#Unit 3. Fundamental Processes

Transition takes place due to Tautomeric Shift in Nitrogenous bases Spontaneously.

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#Id: 632

#Unit 3. Fundamental Processes

Transversion takes place due to Oxidation of Nitrogenous bases especially of Guanine due to reactive oxygen species.

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#Id: 633

#Unit 3. Fundamental Processes

Transition and Transversion showed up during replication only.

TLS Online TPP Program

#Id: 634

#Unit 3. Fundamental Processes

HNO₂ or Nitrous Acid is deaminating agent causes removal of –NH2 for nitrogenous bases.