His design allowed air inside the flasks to be exchanged with air from the outside, but prevented the introduction of any airborne microorganisms, which would get caught in the twists and bends of the flasks’ necks.

TLS Online TPP Program

#Id: 1528

#Unit 2. Cellular Organization

Many MAPs are positively charged and bind to microtubles through electrostatic interactions.

TLS Online TPP Program

#Id: 1529

#Unit 2. Cellular Organization

MAPs are members of the tau family of proteins, which stabilize microtubules:

Tau 

MAP2

MAP4

TLS Online TPP Program

#Id: 1530

#Unit 2. Cellular Organization

MAPs (Tau, MAP2, MAP4 ) have two key domains:

1. Side-binding domains

2. Projection domains

TLS Online TPP Program

#Id: 1531

#Unit 2. Cellular Organization

When stabilizing MAPs coat the outer wall of a microtubule, they can increase the growth rate of microtubules or reduce catastrophe frequency.

TLS Online TPP Program

#Id: 1532

#Unit 2. Cellular Organization

The activity of the MAPs is regulated by the reversible phosphorylation of their projection domains.

TLS Online TPP Program

#Id: 1533

#Unit 2. Cellular Organization

Microtubule-affinity regulating kinase (MARK/Par-1) is a key modulator of tau proteins.