The high-mobility group (HMG) are nonhistones and may contain Transcriptional Factors.

TLS Online TPP Program

#Id: 3286

#Unit 3. Fundamental Processes

In BER, A DNA glycosylase recognizes a damaged base (in this case, a uracil) and cleaves between the base and deoxyribose in the backbone.

TLS Online TPP Program

#Id: 3289

#Unit 3. Fundamental Processes

n BER,  An AP endonuclease cleaves the phosphodiester backbone near the AP site

TLS Online TPP Program

#Id: 3290

#Unit 3. Fundamental Processes

In BER,  DNA polymerase I initiates repair synthesis from the free 3’ hydroxyl at the nick, removing (with its 5’-3’ exonuclease activity) and replacing a portion of the damaged strand. 

TLS Online TPP Program

#Id: 3291

#Unit 3. Fundamental Processes

In BER, The nick remaining after DNA polymerase I has dissociated is sealed by DNA ligase.

TLS Online TPP Program

#Id: 3293

#Unit 3. Fundamental Processes

Base excision repair of a T∙G mismatch. 

TLS Online TPP Program

#Id: 3297

#Unit 3. Fundamental Processes

oxoG:A repair, Oxidation of guanine produces oxoG. 

The modified base can be repaired before replication by DNA glycosylase via the base excision pathway. 

If replication occurs before the oxoG is removed, resulting in the misincorporation of an A, then a fail-safe glycosylase can remove the A, allowing it to be replaced by a C. 

This provides a second opportunity for the DNA glycosylase to remove the modified base.