In augmented unipolar limb lead, two of the limbs are connected through the negative terminal of the electrocardiograph, and the third limb is connected to the positive terminal.

TLS Online TPP Program

#Id: 9688

#Unit 4. Cell Communication and Cell Signaling

GSVs tethered to the Golgi matrix, by a protein termed TUG (Tether containing a UBX domain for GLUT4).

TLS Online TPP Program

#Id: 9689

#Unit 4. Cell Communication and Cell Signaling

Binding of insulin to its receptor triggers activation of a protease that catalyzes a site-specific endoproteolytic cleavage of TUG

TLS Online TPP Program

#Id: 9690

#Unit 4. Cell Communication and Cell Signaling

Released N-terminal TUG fragment bind to the kinesin, initiates the microtubule-based movement of the GSVs to the plasma membrane.

TLS Online TPP Program

#Id: 9691

#Unit 4. Cell Communication and Cell Signaling

Movement of the GSVs to the plasma membrane is regulated by two monomeric GTP-binding proteins -RalA and Rab10

TLS Online TPP Program

#Id: 9692

#Unit 4. Cell Communication and Cell Signaling

Insulin receptor activates the PI-3 kinase/PKB pathway

TLS Online TPP Program

#Id: 9693

#Unit 4. Cell Communication and Cell Signaling

Active PKB, phosphorylates

and inhibits the GTP→GDP hydrolysis activity of two GAP

proteins - AS160 and RGC