Nurturing Life Sciences
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#Unit 5. Developmental Biology
Antigen pieces are held within the binding groove of a cell surface protein called the major histocompatibility complex (MHC) molecule which recognized by T cell
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Class I MHC, glycoproteins expressed on the surface of nearly all nucleated cells; the major function of the class I is presentation of endogenous peptide antigens to CD8+ T cells.
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Class II MHC glycoproteins expressed predominantly on pAPCs, where they primarily present exogenous antigenic peptides to CD4+ T cells.
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Class III MHC genes encode several different proteins, some with immune functions, include the complement components C4, C2, and factor B, TNF-α and Lymphotoxin-α [TNF- α].
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Daudi tumor cells, which are unable to synthesize β 2-microglobulin.
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