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TLS Online TPP Program

#Id: 4700

In the Hymenoptera (ants, bees, and wasps), Females develop from the queen’s fertilized eggs and are diploid. Males develop from the queen’s unfertilized eggs and are haploid—their sperm are genetically identical

#Unit 11. Evolution and Behavior #Altruism and Evolution-Group Selection #Part B Pointers
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TLS Online TPP Program

#Id: 10015

#Unit 4. Cell Communication and Cell Signaling

A cytosolic complex contains
kinases Fused ; PKA, GSK3β, and CK1, Ci, and SUFU
TLS Online TPP Program

#Id: 10016

#Unit 4. Cell Communication and Cell Signaling

Cytosolic complex is bound to a microtubule by the kinesin-related motor protein Costal-2 (Cos2).
TLS Online TPP Program

#Id: 10017

#Unit 4. Cell Communication and Cell Signaling

In this complex, Ci becomes phosphorylated in a series of steps catalyzed by PKA, GSK3β, and CK1.
TLS Online TPP Program

#Id: 10018

#Unit 4. Cell Communication and Cell Signaling

The phosphorylated Ci is proteolytically cleaved by the ubiquitin-proteasome pathway, generating an N-terminal fragment Ci75, which functions as a transcriptional repressor of Hh target genes.
TLS Online TPP Program

#Id: 10019

#Unit 4. Cell Communication and Cell Signaling

Hh binds to Ptc, causing Ptc to be endocytosed from the cell surface and degraded, relieving the inhibition of Smo.
TLS Online TPP Program

#Id: 10020

#Unit 4. Cell Communication and Cell Signaling

The C-terminal segment of Smo binds Cos2, and Smo is stabilized from degradation