The absorption spectrum of a chromophore is only partly determined by its chemical structure. The environment also affects the observed spectrum, which mainly can

be described by three parameters:

protonation/deprotonation (pH, RedOx);

• solvent polarity (dielectric constant of the solvent); and

• orientation effects.

TLS Online TPP Program

#Id: 8649

#Unit 2. Cellular Organization

During S phase and mitosis, 

Cdh1 is phosphorylated, Cdh1 dissociates from APC/C, and APC/C becomes inactive.

TLS Online TPP Program

#Id: 8650

#Unit 2. Cellular Organization

G1/S phase CDKs phosphorylate Cdh1 at the 

G1-S phase transition

TLS Online TPP Program

#Id: 8651

#Unit 2. Cellular Organization

S phase cyclin-CDK accumulates in late G1 , they are immediately inactivated by binding of a CKI called Sic1

TLS Online TPP Program

#Id: 8652

#Unit 2. Cellular Organization

TLS Online TPP Program

#Id: 8653

#Unit 2. Cellular Organization

Degradation of Sic1 is induced by its phosphorylation by G1/S phase CDKs.

TLS Online TPP Program

#Id: 8654

#Unit 2. Cellular Organization

Sic1 inhibitor is degraded following its ubiquitinylation by the SCF ubiquitin-protein ligase