Nurturing Life Sciences
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#Unit 2. Cellular Organization
H2AZ variant has 60% sequence identity with canonical H2A and involved in gene activation, heterochromatin–euchromatin boundary formation, cell-cycle progression.
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Mammalian macroH2A is enriched in the inactive X chromosome in females, which is assembled into a silent, heterochromatic state
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Mammalian H2ABbd variant is excluded from the inactive X and forms a less stable nucleosome than canonical H2A
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The second level of organization is the coiling of the 10-nm fiber of nucleosomes into a helical array to constitute the fiber of diameter 30 nm.