The fibrin is initially a loose mesh of interlacing strands. It is converted by the formation of covalent cross linkages to a dense, tight aggregate (stabilization). 

TLS Online TPP Program

#Id: 5796

#Unit 7. System Physiology – Animal

The major hormonal product of the coupling reaction is the molecule thyroxine (T4), which is formed when two molecules of DIT are joined together; the thyroxine then remains part of the thyroglobulin molecule.

TLS Online TPP Program

#Id: 5797

#Unit 7. System Physiology – Animal

Iodinated Tyrosines (MIT and DIT) are deiodinated by a microsomal iodotyrosine deiodinase, to recover iodine and bound tyrosines and recycle them for additional rounds of hormone synthesis.

TLS Online TPP Program

#Id: 5798

#Unit 7. System Physiology – Animal

The thyroid hormone receptor usually forms a heterodimer with retinoid X receptor (RXR) at specific thyroid hormone response elements on the DNA

TLS Online TPP Program

#Id: 5799

#Unit 7. System Physiology – Animal

TLS Online TPP Program

#Id: 5800

#Unit 7. System Physiology – Animal

Thyrotropin-releasing hormone (TRH) Tripeptide (amide—pyroglutamyl-histidylproline-amide) Stimulates secretion of TSH by thyrotropes

TLS Online TPP Program

#Id: 5801

#Unit 7. System Physiology – Animal

TRH receptors in the pituitary cell membrane activates the phospholipase second messenger system, leads to TSH release.