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TLS Online TPP Program

#Id: 5192

The complex of IXa and VIIIa activate factor X. 


#Unit 7. System Physiology – Animal #Blood and circulation #Part B Pointers
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TLS Online TPP Program

#Id: 7959

#Unit 2. Cellular Organization

Unfolded-protein response
Key protein –Ire1 promotes formation of Hac1
TLS Online TPP Program

#Id: 7960

#Unit 2. Cellular Organization

Binding of BiP to the luminal domain of monomeric Ire1 prevents formation of the Ire1 dimer.
TLS Online TPP Program

#Id: 7961

#Unit 2. Cellular Organization

Quantity of free BiP in the ER lumen determines the relative proportions of monomeric and dimeric Ire1.
TLS Online TPP Program

#Id: 7962

#Unit 2. Cellular Organization

Hac1 activates transcription of genes encoding several protein-folding catalysts.
TLS Online TPP Program

#Id: 7963

#Unit 2. Cellular Organization

A hereditary form of emphysema illustrates the detrimental effects that can result from misfolding of proteins in the ER.
TLS Online TPP Program

#Id: 7964

#Unit 2. Cellular Organization

Emphysema caused by a point mutation in -antitrypsin, which is normally secreted by hepatocytes and macrophages.