Plasmin (fibrinolysin) is the active component of the plasminogen (fibrinolytic) system. 

TLS Online TPP Program

#Id: 7430

#Unit 5. Developmental Biology

A second glycoprotein secreted during starvation is CMF (conditioned medium factor)

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#Id: 7431

#Unit 5. Developmental Biology

CMF stimulates gene expression in parallel with PSF, and both signals potentiate cAMP signalling by inducing genes involved in cAMP synthesis and detection

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#Id: 7432

#Unit 5. Developmental Biology

Newly activated genes are:

Adenylate cyclase A (ACA)

PKA

cAMP receptors (cARs)

Extracellular cAMP phosphodiesterase PdsA

An intracellular cAMP phosphodiesterase RegA

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#Id: 7433

#Unit 5. Developmental Biology

Once all proteins are functioning, a few starving cells start to emit cAMP pulses.

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#Id: 7434

#Unit 5. Developmental Biology

Chemotaxis of Dictyostelium myxamoebae is a result of spiral waves of cAMP.

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#Id: 7435

#Unit 5. Developmental Biology

Neighboring cells respond to cAMP in two ways:

Initiate a movement toward the cAMP pulse for about a minute

Release cAMP of their own