Nurturing Life Sciences
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#Unit 3. Fundamental Processes
“Quartets” of G residues is characteristic of Telomere
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Short repeating sequence from the human telomere forms three stacked G quartets.
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Telomerase, a reverse transcriptase that contains an RNA template, repeatedly adds TTAGGG repeats
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Embryonic cells, germ-line cells, and stem cells produce telomerase, but most human somatic cells produce only a small amount of telomerase as they enter S phase.
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As a result of their modest telomerase activity, their telomeres shorten with each cell cycle.
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Extensive shortening of telomeres is recognized by the cell as a double-strand break and consequently triggers cell cycle arrest and apoptosis.