Adaptive introgression

When the incorporation of a foreign variant leads to an increase of the fitness of the recipient pool.

TLS Online TPP Program

#Id: 9053

#Unit 4. Cell Communication and Cell Signaling

Binding of cAMP by an R subunit of PKA occurs in a cooperative fashion; i.e., binding of the first cAMP molecule to CNB-B lowers the Kd for binding of the second cAMP to CNB-A.

TLS Online TPP Program

#Id: 9054

#Unit 4. Cell Communication and Cell Signaling

The activated β2-adrenergic receptor induces GDP-->GTP exchange on a stimulatory G protein (Gs).

TLS Online TPP Program

#Id: 9055

#Unit 4. Cell Communication and Cell Signaling

TLS Online TPP Program

#Id: 9056

#Unit 4. Cell Communication and Cell Signaling

TLS Online TPP Program

#Id: 9057

#Unit 4. Cell Communication and Cell Signaling

glutamate (E200) and arginine (R209) participate in binding of cAMP, which causes a conformational change in the loop that prevents binding of the loop to the C subunit.

TLS Online TPP Program

#Id: 9058

#Unit 4. Cell Communication and Cell Signaling

Epinephrine --> Gαs-GTP-->Adenylyl cyclase-->cAMP-->PKA