Thick segment of the ascending limb of loop of Henle, has thick epithelial cells that have high metabolic activity and are capable of active reabsorption of sodium, chloride, and potassium

TLS Online TPP Program

#Id: 6283

#Unit 3. Fundamental Processes

TLS Online TPP Program

#Id: 8696

#Unit 1. Molecules and their Interaction Relevant to Biology

TLS Online TPP Program

#Id: 3226

#Unit 3. Fundamental Processes

Numerous proteins, including XP products and the transcription factor TFnH, are involved in eukaryotic nucleotide excision repair. 

TLS Online TPP Program

#Id: 8596

#Unit 2. Cellular Organization

Septins 

GTP-binding proteins 

serve as an additional filament system in all eukaryotes except terrestrial plants. 

TLS Online TPP Program

#Id: 6301

#Unit 3. Fundamental Processes

The closed complex is converted into an open complex of 1.3 turns of the double helix in a series of steps by first “melting” a short region of DNA around the -10 region, giving an unstable intermediate open complex within the sequence bound by the enzyme.  Two bases in the non-template strand of the –10 element (A11 and T7) flip out from their base-stacking interactions and instead insert into pockets within the s protein where they make more favorable interactions. By stabilizing the single-stranded form of the –10 element, these interactions drive melting of the promoter region.