The DNA-binding domain occupies residues 1–59. It contains two a-helices separated by a turn. This is a common DNA-binding motif known as the HTH (helix-turn-helix); the two a-helices fit into the major groove of DNA

TLS Online TPP Program

#Id: 10335

#Unit 4. Cell Communication and Cell Signaling

TLS Online TPP Program

#Id: 10336

#Unit 4. Cell Communication and Cell Signaling

They are pAPCs

Have surface marker  CD19

Antibodies at surface of b cell – IgM, IgD

Cause humoral immunity or antibodies mediated immunity

TLS Online TPP Program

#Id: 10337

#Unit 4. Cell Communication and Cell Signaling

Surface protein on B cell

CR2(CR21)

CD19

TAPA-1(CD81)

mIg 

Igα/ Igβ

(CD79a and CD79B)

TLR

CD40

B7(CD80/86)

ICAM-1

MHC-1 and 2 both

CD 22

TLS Online TPP Program

#Id: 10338

#Unit 4. Cell Communication and Cell Signaling

Step involve in formation of mature B-cell

TLS Online TPP Program

#Id: 10339

#Unit 4. Cell Communication and Cell Signaling

TLS Online TPP Program

#Id: 10340

#Unit 4. Cell Communication and Cell Signaling

B cell Development